Resume of C. Richard Kinsolving, Ph.D.

The Immune Recovery Clinic of the Immune Recovery Foundation

C. Richard Kinsolving, Ph.D.

EDUCATION:
Ph.D Pharmacology (1970) Emory University
MA Physiology/Chemistry (1962) Vanderbilt University
BA Chemistry (1957) Tennessee Tech. University
GRADUATE STUDIES:
(1974-1975) Fairleigh Dickinson University
(1967) Princeton University
(1966) Seaton Hall University
(1959) Marine Biological Labs (Woods Hole)
(1958) Stanford University

ACADEMIC:
Associate Professor of Pharmacology (Adjunct), Department of Pharmacology, St. John's University, Long Island, New York (1974-1979)
Assistant Professor (Pharmacology), Cincinnati Technical College, Cincinnati, Ohio (1972-1974)
Instructor (Anatomy, Physiology, Pharmacology), School of Nursing, Nashville, Tennessee, University of Tennessee Extension (1959-1962)
Lecturer for ASPET on "Pharmacologists in Industry" to Medical and Pharmacy Schools, Northeast Region. (1979 - 82)

PROFESSIONAL:
BioPharmacon Inc. ; Bradenton, Florida
C.E.O. (2/99 - present, Founder)
A pharmaceutical development group
BESTECHNOLOGY, INC ; Sarasota, Florida
President (12/91 - 9/95: Co- Founder), Director to present
A nonmedical biological R & D company producing bacterial preparations for industrial use.
IMMUNO-Rx, INC. ; Sarasota, Florida
President and CEO (12/92- 2/99, Founder)
FISONS PHARMACEUTICALS (formerly PENNWALT PHARMACEUTICAL DIVISION, Rochester, NY (3/77 - 9/89)
Director of Strategic Planning (5/87 - 9/89)
Director Biological and Chemical Sciences Division (3/81 - 5/87)
Director, Department of Pharmacology (3/77 - 3/81)
USV PHARMACEUTICAL COMPANY, TUCKAHOE, NY (74-77)
Head - General Pharmacology Section (CNS and Metabolic Disease)
Head - Immunology
Acting Head - Toxicology Section
MERRELL-NATIONAL LABORATORIES, CINCINNATI, OHIO (12/70 - 6/74)
Dept. of Pharmacology Head - Autonomic Pharmacology & Gastroenterology (5/72-6/74)
Group Leader - Immunopharmacology (12/70-5/72)
WARNER-LAMBERT RESEARCH INSTITUTE, MORRIS PLAINS, NJ (10/62-8/68)
Group Leader - Allergy & Hypersensitivity, Department of Pharmacology.

SOCIETY MEMBERSHIPS:
American Association for the Advancement of Science
American Chemical Society
American Society of Pharmacology and Experimental Therapeutics
Archaeological Institute of America
Asociacion Mexicana de Farmacologia
New York Academy of Science
(Elected Fellow of the Academy 1980)
Co-organizer. Symposium, November 1987 - Antifungal Drugs
Inter-American Society for Chemotherapy (Charter member 1984) Chairman, section of Medicinal Chemistry and Pharmacology
(1988-91) - Vice President (1989-1992), Board of Directors (1993-)
International Society of Chemotherapy

PATENTS:
1. U.S. 3,806,526 (1974) 10. U.S. 4,386,105 (1983)
2. U.S. 3,829,433 (1974) 11. U.S. 4,486,601 (1984)
3. U.S. 3,862,173 (1975) 12. U.S. 4,520,132 (1985)
4. U.S. 3,878,217 (1975) 13. U.S. 4,537,908 (1985)
5. U.S. 3,900,558 (1975) 14. U.S. 4,557,865 (1985)
6. U.S. 3,931,197 (1976) 15. U.S. 4,600,782 (1986)
7. U.S. 3,946,022 (1976) 16. U.S. 4,614,810 (1986)
8. U.S. 3,965,257 (1976) 17. U.S. 4,730,063 (1989)
9. U.S. 4,351,847 (1982)
Four additional patent applications are pending.
The above patents cover antihistamines, immunomodulators, antifungal, antiviral and CNS agents.

PUBLICATIONS:
l. Post, R.L., C.R. Merritt, C.R. Kinsolving and C.D. Albright. Membrane Adenosine Triphosphatase as a Participant in the Active Transport of Sodium and Potassium in the Human Erythrocyte. J. Biol. Chem. 235:1796 (l960).
2. Kinsolving, C.R. and R.L. Post. Identification of a Transport Adenosine Triphosphatase Activity in Guinea Pig Kidney. The Physiologist 3:No. 3 (l960).
3. Kinsolving, C.R., R.L. Post and D.L. Beaver. Sodium Plus Potassium Transport Adenosine Triphosphatase Activity in Kidney. J. Cell. and Comp. Physiol. 62:85 (l963).
4. Megal, H., A. Raychaudhuri, S. Goldstein, C.R. Kinsolving, I. Shemano and J.G. Pichael. Paradoxical Effects of Tilorone Hydrochloride on Humoral and Cellular-Mediated Immune Responses in Mice and Rats. Fed. Proc. 32:1021 (1973).
5. Megal, H., A. Raychaudhuri, S. Goldstein, C.R. Kinsolving and G. Michael. Tilerone: Its Selective Effects on Cell Mediated Immunity. Proc. Soc. Exp. Biol. Med. 145: 513 (1974).
6. Kinsolving, C.R., N.L. Munro and A.A. Carr. Histamine Receptors I: Separation of the CNS and H-1 Receptor Effects of Antihistamines. The Pharmacologist l5: 220 (1973).
7. Carr, A.A. and C.R. Kinsolving. Structure-Activity Relationships Among a New Series of Antihistamines. The Pharmacologist 15: 220 (1973).
8. Carr, A.A., C.R. Kinsolving and D.R. Meyer. Derivatives of aa-Diphenyl-4-Piperidinemethanol, 4- Diphenylmethylenepiperidine and 4-Diphenylmethyl-enepiperidine and 4-Diphenylmethylpiperidine as Antihistamines. ACS Abstracts (1973).
9. Kinsolving, C.R. and N.L. Munro. A Comparison of the Bioavailability of Three Dosage Forms of Terfenadine. Drug Metabolism Reviews 4: 285-290 (1975).
10. Kinsolving, C.R., A.R. Johnson and N.C. Moran. The Uptake of a Substituted Acridone by Rat Mast Cells in Relationship to Histamine Release: A Possible Indicator of Exocytosis-Induced Expansion of the Plasma Membrane. J. Pharmacol. Exp. Therap. 192: 654-669 (1975).
11. Moran, N.C. and C.R. Kinsolving. Expansion of the Plasma Membrane of Rat Mast Cells Resulting from Exocytosis. Federation Proceedings 34: 718 (1975).
12. Kinsolving, C.R. Nexeridine Hydrochloride: A Cyclohexyl Ester Analgesic. Proc. Third Natl. Cong. Pharm. (Morelia, Mexico) 3: 99 (1979).
13. Wu, E.S.C., Cole, T., Davidson, T., Kinsolving, C.R., Blosser, J., Parker, R. Antihypertensive flavonoxypropanolamines. Flavodilol 7-(3-propylamine-2-hydroxypropoxy)flavone, and its analogs. Pharmacologist 27(3): 809 (1985)
14. Watkins, B.E., Blosser, J.C. and Kinsolving, C.R. Flavodilol: Biological profile of a novel antihypertensive agent. 186th National ACS Meeting, September 1985.
15. Watkins, B.E., Milgate, T.E., Borelli, A.R., Kaiser, F.C., Kinsolving, C.R., Parker, R.B. and Wu, E.S.C. Flavodilol: Characterization of a novel antihypertensive agent. The Pharmacologist 27: 261, 1985.
16. Blosser, J., Kaiser, F., Kinsolving, C.R., Parker, R.B., McCreedy, S., Milgate, T., and Watkins, B. Effects of antihypertensive doses of flavodilol on indices of peripheral adrenergic function. Pharmacologist 27(3): 811 (1985)
17. R dov, L.A., Murray, R.J. and Kinsolving, C.R. Immunological profile of PR879-317A, a new immunomodulatory agent. Annual Conference II of the Inter-American Society of Chemotherapy, Inc., Tampa, FL. 1985.
18. Warren, R.P., Healey, M.C., Johnston, A.V., Sidwell, R.W., Radov, L.A. Murray, R.J. and Kinsolving, C.R. Incubation in PR879-317 augments immune function of peripheral blood mononuclear cells (PBMC) from patients with Down syndrome. Sixth International Congress of Immunology, Toronto, Ontario, Canada 1986.
19. Blosser, J.C. Kaiser, F.C., Kinsolving, C.R., Parker, R.B., McCreedy, S.A., Milgate, T.E. and Watkins, B.E. Effects of antihypertensive doses of flavodilol on indices of peripheral adrenergic function. The Pharmacologist 27:261, 1985.
20. Georgiev, V. St., Radov, L.A., Kinsolving, C.R., Griffith, R.C., Zazulak, W.I., Kamp, D.K., Trusso, L.A., Mack, R.A.: "Synthesis and Biological Activity of 2-Adamantanone Oxime Ester Derivatives", Eur. J. Med. Chem., Chim. Ther. 21: 315 (1986).
21. Georgiev, V. St., Saeva, G.A., Kinsolving, C.R.: New Substituted 4-Azatricyclo{4.3.1.13,8 }undecane Derivatives", J. Heterocycl. Chem. 23: 1032 (1986).
22. Borrelli, A.R., Blosser J.C., Barrantes, M., Colombo, P., Kinsolving, C.R., Ordy, J.M. and Watkins, B.E. Temporal concordance of anorectics, behavioral, cardiovascular and amphetamine receptor binding activity of phenethylamines in rats. Fed. Proc. 45: 609, 1986.
23. Borrelli, A., Blosser, J., Barrantes, M., Colombo, P., Kinsolving, C.R., Ordy, J.M., and Watkins, B. Temporal concordance of anorectic, behavioral, cardiovascular and amphetamine receptor binding activity of phenylethylamines in rats. Fed. Proc. 45(3): 2647 (1986).
24. Georgiev, V. St., Mack, R.A., Kinsolving, C.R.: "Synthesis of Substituted 4,5-Dihydro-4-oxo-2-{(2-trans-phenylcyclopropyl)amino}-3-furancarboxylic Acids and Ethyl Esters", Heterocycles 24:3195 (1986).
25. Warren, R.P., Healey, M.C., Johnston, A.V., Sidwell, R.W., Radov, L.A., Murray, R.J. and Kinsolving, C.R. PR879-317A enhances in vitro immune activity of peripheral blood mononuclear cells from patients with Down syndrome. (Int. J. Immunopharmac. 9:919 (1987).
26. Georgiev, V.St., Acker, C.G., Kinsolving, C.R.: "Novel Substituted Adamantane-spiro-5-oxazolidine Derivatives", Heterocycles 25: 469 (1979).
27. Wu, E.S.C., Cole, T., Davidson, T., Blosser, J., Borrelli, A., Kinsolving, C.R., Parker, R. and Milgate, T. Flavone 1. Synthesis and antihypertensive activity of 3-phenylflavooxypropanol-amines without beta-adrenoceptor antagonism. J. Med. Chem. 30:788-792 (1987).
28. Bennett, G.A., Mullen, G.B., Mitchell, J.T., Allen S.D., Kinsolving, C.R., Georgiev, V.St.: "In vitro Antifungal Activity of 5-(phenyl or phenoxyalkyl)-3-(2-furanyl)-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazoldines", Ann. N.Y. Acad. Sci. 544: 384 (1988).
29. Ordy, J.M., Palmer, G.C., Strand, J.C. Mullen, G.B., Kinsolving, C.R., Georgiev, V.St.: "Comparisons of Ketoconazole, PR 967-234 and PR 967-248 As Antifungals in the Rat Model of Candidal Vaginitis Based on Efficacy and Safety Profiles", Ann. N.Y. Acad. Sci. 544: 387 (1988).
30. Mullen, G.B., Maryniak, D.M., Swift, P.A., Allen, S.D., Mitchell, J.T., Kinsolving, C.R., Georgiev, V.St.: "Substituted 5-Phenoxyalkyl-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines. Antifungal Activity and Structure-Activity Relationship Studies", Ann. N.Y. Acad. Sci. 544: 359 (1988).
31. DeCory, T.R., Mullen, G.B., Mitchell, J.T., Allen, S.D., Kinsolving, C.R., Georgiev, V.St.: "In Vitro Antifungal Activity of Novel Substituted 3,5-Diphenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine Derivatives", Ann. N.Y. Acad. Sci. 544: 363 (1988).
32. DeCory, T.R., Swift, P.A., Mullen, G.B., Mitchell, J.T., Allen, S.D., Kinsolving, C.R., Georgiev, V.St.: "Cis-3-(Substituted phenyl)-3-(1H-imidazol-1-ylmethyl)-2-methyl-5-{[(substituted phenyl)thio(or amino)]methyl}isoxazolidines. In Vitro Antifungal Activity and Structure-Activity Relationship Studies", Ann. N.Y. Acad. Sci. 544: 366 (1988).
33. Bennett, G.A., Swift, P.A., Mullen, G.B., Allen, S.D., Mitchell, J.T., Kinsolving, C.R., Georgiev, V.St.: "Novel Antifungal 3-(Substituted phenyl)-3-(1H-1,2,4-triazol-1-ylmethyl)-2-methyl-5-[(substituted phenoxy)methyl]isoxazolidine Derivatives. Structure-Activity Relationships Studies", Ann. N.Y. Acad. Sci. 544: 369 (1988).
34. Swift, P.A., Bennett, G.A., Muller, G.B. Mitchell, J.T., Allen, S.D., Kinsolving, C.R., Georgiev, V.St.: "5-Alkyl (or alkenyl)-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine Derivatives. In Vitro Antifungal Activity and Structure-Activity Relationship Studies", Ann. N.Y. Acad. Sci. 544: 381 (1988).
35. Bennett, G.A., Swift, P.A., Mullen, G.B., Mitchell, J.T., Allen, S.D., Kinsolving, C.R., Georgiev, V.St.: "In Vitro Antifungal Activity and Structure-Activity Relationship Studies of A Series of Novel Substituted 3,5-Diphenyl-3-(1H-1,2,4-triazol-1-ylmethyl)-2-methylisoxazolidines", Ann. N.Y. Acad. Sci. 544: 375 (1988).
36. Maryniak, D.M., Mullen, G.B., Allen, S.D., Mitchell, J.T., Kinsolving, C.R., Georgiev, V.St.: "In Vitro Antifungal Activity and Structure-Activity Relationship Studies of Novel 5-Acyloxyalkl-3-phenyl-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine Deriviatives", Ann. N.Y. Acad. Sci. 544: 378 (1988).
37. Maryniak, D.M., Mullen, G.B., Mitchell, J.T., Allen, S.D., Kinsolving, C.R., Georgiev, V.St.: Novel Antifungal 5-Alkoxyalkl-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine Derivatives", Ann. N.Y. Acad. Sci. 544: 373 (1988).
38. Mullen, G.B., Swift, P.A., Maryniak, D.M., Allen, S.D., Mitchell, J.T., Kinsolving, C.R., Georgiev, V.St.: "Studies on Antifungal Agents. Part 22. 3-Aryl-5-[(aryloxy)alkyl]-3-[(1H-imidazol-1-yl)methyl]-2-methylisoxazolidines and Related Derivatives", Helv. Chim. Acta., 71: 1672 (1988)
39. Mack, R.A., Zazulak, W.I., Radov, L.A., Baer, T.E., Stewart, J.D., Elzer, P.H., Kinsolving, C.R., Georgiev, V.St.: "Drug-Induced Modifications of the Immune Response. 12. 4,5-Dihydro-4-oxo-2-(substituted amino)-3-furancarboxylic Acids and Derivatives As Novel Antiallergic Agents", J. Med. Chem. 31: 1910 (1988).
40. Mullen, G.B., DeCory, T.R., Michell, J.T., Allen, S.D., Kinsolving, C.R., Georgiev, V.St.: "Studies on Antifungal Agents. 23. Novel Substituted 3,5-Diphenyl-3-(1H-imidazol-1-ylmethyl)-2-alkylisoxazolidine Derivatives", J. Med. Chem. 31: 2008 (1988)
41. Wu, E.S.C., Cole, T.E., Kinsolving, C.R., and Watkins, B.E. "Flavores 2. Synthesis and Structure Activity Relationships of Flavadilol." J. Med. Chem. 32: 183 (1989).
42. Blosser, J.C., McCreedy, S., Parker, R.B., Kinsolving, C.R. and Watkins, B. Flavodilol, a new antihypertensive agent which preferentially depletes peripherol biogenic amines. J. Cardiovasc. Pharmacol.
43. Kinsolving, C.R., Watkins, B., Parker, R.B., Wu, E.S.C., Milgate, T., Borrelli, A.R., Kaiser, F.C., Montesano, K.M. and Strand, J.C. Flavodilol: a new antihypertensive agent J. Cardiovascular Pharmocol.
44. Warren, R.P., Sidwell, R.W., Huffman, J.H., Call, E.W., Healey, M.C., Johnston, A.V., Radov, L.A., Murray, R.J. and Kinsolving, C.R. Effect of PR879-317A on immune parameters of mice infected with murine hepatitis. Int. J. Immunopharmac.
45. Palmer, E.C., Ordy, M.J., Simmons, R.D., Strand, J.C., Radov, L.A., Mullen, G.B., Kinsolving, C.R., Georgiev, V.St., Mitchell, J.T. and Allen, S.D. Selection of orally active antifungals from 3,5-substituted isoxazolidine derivatives based on acute efficacy/safety profiles. Antimicrobial. Agents Chemo.

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